Association of Silent Information Regulator 1 (Sirt1) Gene Polymorphism with the Pathogenesis of Diabetic Nephropathy

Introduction: Diabetic nephropathy (DN) is one of the major microvascular complications diabetes mellitus. Patients with diabetic are at a higher risk morbidity and mortality than those without nephropathy. In this case, early diagnosis prevention DM crucial. SIRT1, which among seven members sirtuins, recognized as an important element in pathogenesis type 2 diabetes, therefore it has several actions that will be further discussed study. This study analyse relationship between SIRT1 gene polymorphism serum sirt1 Aim study: evaluation association Silent Information Regulator1 (SIRT1) protein patients their role Subjects Methods: was carried out on 120 subjects matched age sex. They were divided into 3 groups: (Group 1: 40 patients, Group 2: nephropathy, 3: healthy control ) to discuss Results: The mean levels significantly increasing group diabetics controls, while not significant DN group. Conclusion: Basedon study, factor development progression DN.